The objective of this study was to examine the impact of a P aw of 10, 20 and 30 cmH 2O on the estimation of lung volumes and stereologically assessed parameters that describe the lung structure in developing mouse lungs. These differences have raised concerns about whether the inflation fixation of neonatal mouse lungs with the airway pressure ( P aw) used for the inflation fixation of adult mouse lungs may cause distortion of the neonatal mouse lung structure, leading to the generation of artefacts in subsequent analyses. The immature lung is structurally and functionally distinct from the adult lung, and has a smaller volume than does the adult lung. ![]() ![]() These stereological principles are now being applied to the study of the evolution of the lung architecture over the course of prenatal and postnatal lung development in mouse neonates and adolescents. The morphometric analysis of lung structure using the principles of stereology has emerged as a powerful tool to describe the structural changes in lung architecture that accompany the development of lung disease that is experimentally modelled in adult mice.
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